Hello. My name is Leslie Moselle and I'm from Tampa, Florida. And, on behalf of Expert Village, these are the signs of depression. For a doctor or other health professional to diagnose depression, most of the following signs and symptoms must be present for at least two weeks. Low Self-Esteem or Self-Loathin ith this symptom of depression, you will have feelings of worthlessness and excessive guilt. You'll be overly critical to your perceived faults and mistakes, not allowing you to take part in the things that you once loved. What you do and feel will most likely be followed by statements such as "I can't do anything right," "I give up," "I hate myself," or "I am worthless." All of these thoughts will leave you less inclined to take action in your life, in turn, leading to more destructive symptoms of depression.