How often should I replace my nasal CPAP mask? This is a question that is often posed to me. I recommend that patients change their CPAP masks every three to six months. Why is this necessary? When your body's natural oil causes deterioration of the mask material this often leads to air leakage and mask discomfort. I'm Doctor Ronald Popper, Medical Director of the Southern California Pulmonary and Sleep Disorders Medical Center in Thousand Oaks, California. To view more videos to help address all of your questions about sleep apnea and other sleep disorders, please view our website, at SleepMD4U.com. Thank you for watching, and always remember, sleep well tonight for a better day tomorrow.